Essential Genes Embody Increased Mutational Robustness to Compensate for the Lack of Backup Genetic Redundancy
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Essential Genes Embody Increased Mutational Robustness to Compensate for the Lack of Backup Genetic Redundancy
Genetic robustness is a hallmark of cells, occurring through many mechanisms and at many levels. Essential genes lack the common robustness mechanism of genetic redundancy (i.e., existing alongside other genes with the same function), and thus appear at first glance to leave cells highly vulnerable to genetic or environmental perturbations. Here we explore a hypothesis that cells might protect ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0168444